Clinical Trial Results

Vitamins, Antioxidants

Vitamin E in aging persons with DS: A randomized, placebo-controlled clinical trial, 2016

Antioxidant intervention attenuates oxidative stress in children and teenagers with DS, 2014.

Prolonged coenzyme Q10 treatment in DS patients: effect on DNA oxidation, 2012. 

DS and dementia: a randomized, controlled trial of antioxidant supplementation, 2011.

Effect of leucovorin (folinic acid) on the DQ of children with DS and influence of thyroid status, 2010

Supplementation with antioxidants and folinic acid for children with DS: randomised controlled trial, 2008. 

Coenzyme Q10 (ubiquinol-10) supplementation improves oxidative imbalance in children with trisomy 21, 2007.

Coenzyme Q10 absorption and tolerance in children with DS: a dose-ranging trial, 2006. 

The effect of acetyl-L-carnitine administration on persons with DS, 2006. 

Effect of the chronic treatment with L-acetylcarnitine in DS, 1994 

Piracetam (Nootropil) 

Piracetam therapy does not enhance cognitive functioning in children with DS, 2001  

Epigallocatechin-3-gallate (EGCG) Green Tea Extract

Safety and efficacy of cognitive training plus epigallocechin-3-gallate in young adults with DS (TESDAD), 2016 

Simvastatin

Towards onset prevention of cognition decline in adults with DS (The TOP-COG study): A pilot randomised controlled trial, 2016

Clinical Trial Results

Donepezil (Aricept)

The efficacy, safety, and tolerability of donepezil for the treatment of young adults with DS, 2009

Dramatic improvement in DS-associated cognitive impairment with Donepezil, 2005.

Effects of donepezil on cognitive functioning in DS, 2003. 

Donepezil for the treatment of language deficits in adults with DS: a preliminary 24-week open trial, 2003.

DS and Alzheimer disease: response to Donepezil, 2002.

A 24-week, double-blind, placebo-controlled trial of donepezil in patients with DS and Alzheimer's disease--pilot study, 2002.  

Rivastigmine (Excelon)

Safety and efficacy of rivastigmine in children with DS: a double blind placebo-controlled trial, 2016

Safety and efficacy of rivastigmine in adolescents with DS: long-term follow-up, 2010

Safety and efficacy of rivastigmine in adolescents with DS: a preliminary 20-week, open-label study, 2006. 

Memantine (Namenda)

Antagonism of NMDA receptors as a potential treatment for DS: a pilot randomized controlled trial, 2012.

Memantine for dementia in adults older than 40 years with DS (MEADOWS): a randomised, double-blind, placebo-controlled trial, 2012.